Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor 7.

As the highly significant comparison in Figure 2 C (all results of significance evaluation given in Table S1 in Supplementary Material) shows attachment of an azide-conjugated PEG-linker at the C -2-ethyl-amino-methyl-group of the 1 H -imidazo-[4,5- c ]-quinolin scaffold (see also Figure S1 in Supplementary Material) ablated TLR7 stimulation of the gardiquimod derivative 2.

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