Antiretroviral Therapy-induced Insulin Resistance and Oxidative Deoxy Nucleic Acid Damage in Human Immunodeficiency Virus-1 Patients.

In India, where there is a genetic predisposition to IR and cardiovascular risk, this impact may be significant.[ 5 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ] IR plays a key role in the pathogenesis of the metabolic syndrome and is frequently detected among HIV patients on ART.[ 22 , 23 , 24 ] Biochemistry of IR: pancreatic b-cells release insulin in response to hyperglycemia, stimulating muscle and adipose tissue to store sugar, and blocking the liver from releasing glucose into circulation.

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