In Cayman, which showed more limited (and marginally non-significant) synergism, CYP9M6 , also a known pyrethroid metabolizer [ 16 ] was consistently overexpressed, though at a moderate level, whereas in Makkah, in which the highest prevalence of deltamethrin resistance but no PBO synergy was observed, no candidate genes were significant.
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Combined target site (kdr) mutations play a primary role in highly pyrethroid resistant phenotypes of Aedes aegypti from Saudi Arabia.
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