Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects.

Comparing the two sets of genes, we observed a highly significant overlap of 193 genes whose expression was altered by either IL-1β treatment and IL-1R8 deficiency (Fischer’s exact test; P value = 2.2e-16; Pearson correlation coefficient = 0.95; 61.7% downregulated and 38.3% upregulated, Supplementary file 3 ).

also in 132,142 other papers