Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets.

Exosome biology and HD Exosomes provide novel intercellular communication system for synaptic functions As described in Supplementary Material Section 2 in Supplementary Datasheet 4 , we first curated a large set of genes possessing neuronal and synaptic functions (SynapseDB) and found highly significant enrichment of the HD datasets (Table S3 , Figure S4 in Supplementary Datasheet 4 ), not surprising for a neurodegenerative disease.

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