Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Res · 2017 · PMC5378179 · PMID 28179366

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of borderline significanceno p-value reported

After these, the next highest ranked gene was BRAF ; although it was of borderline significance (FDR = 0.0508), it is a very strong candidate for a resistance gene because 4/6 of the mutations are at the canonical p.V600 locus.

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