CCL3 and MMP-9 are induced by TL1A during death receptor 3 (TNFRSF25)-dependent osteoclast function and systemic bone loss.

Bone · 2017 · PMC5378198 · PMID 28062298

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highly significantno p-value reported

p -Values of ≤ 0.05 were considered significant and p -values of ≤ 0.01 highly significant. 3 Results 3.1 DR3 ko mice are protected against focal bone erosion in response to collagen-induced arthritis Ablation of TL1A in a model of CIA has previously been demonstrated to partially block inflammation and focal bone erosion associated with the disease pathology [23] .

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