A recent study examining cancer pleiotropy among DNA-repair and DNA-damage signalling pathway variants has also reported a highly significant association with lung cancer for rs3115672, a synonymous variant within MSH5 , in addition to weaker associations with colon and serous ovarian cancers (pleiotropic OR 1.18, 95% CI 1.12-1.24, P =2.53 × 10 −8 ) ( Scarbrough et al , 2016 ).
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Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.
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It is perhaps more surprising that RAD51B did not achieve significance under the SKAT-C test, which considers the potential contribution towards association of both common and rare variants within a region, given that three independent associations have previously been identified at this locus ( Amin Al Olama et al , 2015 ).