a decreasing trendp < 0.0001
an increasing trendp < 0.0001
This analysis showed an increasing trend for TPs using the filgrastim biosimilar (from 34.4% in July 2015 to 49.8% in June 2016; p < 0.0001) compared with a decreasing trend for TPs using lenograstim (from 22.6% in July 2015 to 12.3% in June 2016; p < 0.0001) and pegfilgrastim (from 26.8% in July 2015 to 20.6% in June 2016; p < 0.0001).