Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages.

Accordingly, 50 μM piperine was used in subsequent experiments, since at this concentration it displayed a highly significant ChE‐promoting effect without affecting cell viability. 3.2 Piperine increases ABCA1 protein level ABCA1, ABCG1, and SR‐B1 are the most important transporter proteins for ChE in THP‐1 macrophages.

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