highly significantp = 3.22 × 10 − 25
hypo-methylated DMCs, we observed a highly significant difference in the distribution of hyper- vs. hypo-methylated DMRs with respect to CGIs (Supplementary Fig. 3A, p = 3.22 × 10 − 25 ) and RefSeq genes (Supplementary Fig. 3B, p = 3.22 × 10 − 25 ).