Contrasting the two clusters with the greatest level of enrichment for DDR-related functions (CL5 and CL7), the genes in CL5 provided highly significant resistance not only to multiple platinum compounds, but also to many other classes of DNA damaging agents, including cantharidin, bleomycin, chlorambucil, and others, while those in CL7 were more restricted in activity ( Supplementary Table 4 ).
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Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin.
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