Therefore, care is required when interpreting our results showing an increasing trend in the relative change of PT-INR caused by increased difference in the daptomycin concentrations for Reagents 2 and 3 because the prediction relied on a small number of samples with a high peak concentration.
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Dose-dependent artificial prolongation of prothrombin time by interaction between daptomycin and test reagents in patients receiving warfarin: a prospective in vivo clinical study.
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