cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor.

The decrease was highly significant, with an average change of −18% ( Fig. 1 , P=0.001, F=11.45, df=1,77 for group difference in the 10 regions analyzed using repeated measures, two-way analysis of variance with regions as the within subjects factor, Cohen’s d=0.77).

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