highly significantP -value < 1 ×10 −10
Notably, GO analysis of the 708 up-regulated genes did not show significant enrichment in any specific GO category, but the 733 down-regulated genes showed highly significant enrichment in several categories, with the top three (Benjamini adjusted P -value < 1 ×10 −10 ) classified as neural lineage related categories, including ‘neuron differentiation’, ‘transmission of nerve impulse’ and ‘neuron development’ (Figure 1D ).