The preferred nucleotide contexts of the AID/APOBEC cytidine deaminases have differential effects when mutating retrotransposon and virus sequences compared to host genes.

For 9 out of the 16 motifs we examined, the susceptibility of the vulnerable genes was strongly lower than that of the resistant gene sets to a similar degree, a difference that was highly significant (t-test, P < 2.2 × 10 −16 for all 9 motifs, Fig 5A columns shown in orange box).

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