Barely Significant
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TFAP2A is a component of the ZEB1/2 network that regulates TGFB1-induced epithelial to mesenchymal transition.

Biol Direct · 2017 · PMC5392957 · PMID 28412966

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highly significantno p-value reported
Its target genes are upregulated during EMT (reflected by the red color in the figure) and thus the motif itself is predicted to have a highly significant positive change in activity.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.