The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice.

Eur J Neurosci · 2017 · PMC5396315 · PMID 28186680

Europe PMC DOI

hedged sentences

0.0020

closest p · 0.0× alpha

0.0600

boldest claim

The sentences

highly significantP = 0.002actually significant

As during the initial drug‐free testing, the effect of genotype on choice performance was highly significant, reflecting the pronounced short‐term/working memory impairment in the Gria1 −/− mice ( F 1,14 = 13.52, P = 0.002).

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failed to reach significanceP values > 0.06so close (0.05 < p ≤ 0.1)

On this occasion the Gria1 −/− mice ran faster than WT mice, but the effect of genotype failed to reach significance ( F 1,12 values < 4.20, P values > 0.06).

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