Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene.

However, semi-quantitative analysis revealed no significant difference in scores for hnRNP A1 immunostaining between any of the five pathological groups for DG ( χ 2 = 1.5, p = 0.833) and CA4 ( χ 2 = 3.9, p = 0.421) regions of hippocampus, though there was a trend towards significance in Tcx ( χ 2 = 9.7, p = 0.047), driven by significantly lower scores in FTLD-TDP type C group compared to FTLD-TDP type B ( p = 0.01), FTLD-tau ( p = 0.013) and control ( p = 0.015) groups.

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