Evolution of the endomembrane systems of trypanosomatids - conservation and specialisation.

Rab1 and Rab18 have a complex history, and paralogous expansion of Rab1 or Rab18 may have given rise to two lineage-specific Rabs, KSRX1 and UzRX3, which appear across the Euglenids as tandem genes and are also present in the heterolobosids; however, it may be significant that in T. brucei these proteins have no obvious role in trafficking ( Natesan et al., 2009 ).

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