Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women.

Multiple CpGs reaching genome-wide significance (FDR < 0.05) were found for E2 (87 CpG sites, corresponding p value < 8.36e-06, Supplementary Table S2 ); for PRL (199 CpG sites, corresponding p value < 2.02e-05, Supplementary Table S3 ); and borderline significant for P (3 CpG sites, FDR = 0.06, corresponding p value < 4.30e-07, Supplementary Table S4 ).

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Highly significant differences were found for MC, LH and TST between the two groups; statistical or borderline differences were also found for WHR ( p = 0.037), IRI2 ( p = 0.026) and GLU2 ( p = 0.031), all with higher levels in PCOS patients than in controls.

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