Critically short telomeres and toxicity of chemotherapy in early breast cancer.

When adjusted by age and treatment arm, the linear regression model suggests a quantitative relationship between the percentage of CSTs and the incidence of toxic episodes (B coefficient for percentage of short telomeres = 0.055, P = 0.046; the interpretation of this coefficient value would be that per each 18% increase in the percentage of CSTs a patient would experience 1 more paclitaxel-related events along a 12 weeks-treatment course regardless of the age and treatment arm; the B coefficient for age was borderline significant-1 additional toxic event per each 27 years-increment but in this case, because of the lack of significance, it can not be stated that the increased toxicity would be independent of the status of the telomere variable and treatment arm; P = 0.069).

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