Regional Brain Volumes Moderate, but Do Not Mediate, the Effects of Group-Based Exercise Training on Reductions in Loneliness in Older Adults.

Front Aging Neurosci · 2017 · PMC5403947 · PMID 28487648

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

failed to reach significancep = 0.07so close (0.05 < p ≤ 0.1)

Changes in regional brain volumes as mediators of change in loneliness (H2) Amygdala volume did not change over the course of the intervention (mean = 0.04, p = 0.40; BS 95% CI: −0.04/0.14; d = 0.05), whereas PFC volume decreased (mean = −0.09, p = 0.03; BS 95% CI: −0.17/−0.02; d = −0.10) and a trend for the same in the hippocampus failed to reach significance (mean = −0.07, p = 0.07; BS 95% CI: −0.12/−0.01; d = −0.08).

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may be significantno p-value reported

As the aging population continues to grow rapidly, the burden loneliness poses to public health and our ability to intervene to improve older adults' quality of life may be significant.

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