A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use.

Reprod Biol Endocrinol · 2017 · PMC5408377 · PMID 28449669

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highly significantno p-value reported

That embryos self-correct to highly significant degrees was strongly suggested in a recent mouse study, when early stage embryos, even when highly chimeric for euploid and aneuploid cell lineages, remarkably self-corrected downstream from blastocyst stage.

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