Defining the region of interest for stereology We used the MRI scans to identify the region of interest [the thalamus was chosen as it had highly significant volume loss, and is known to be affected in FTD ( 35 )], and the mouse brain atlas (Franklin and Paxinos, 3rd edition, 2007) to pinpoint specific anatomical structures for delimiting the counting area.
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Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation.
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