Concentration-Dependent Antagonism and Culture Conversion in Pulmonary Tuberculosis.

Clin Infect Dis · 2017 · PMC5411399 · PMID 28205671

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a nonsignificant trendno p-value reported

For example, there was a nonsignificant trend for patients with rifampicin AUC 0-24 /MIC >75th percentile to have a baseline sputum smear grading of 3+, suggesting that confounding by severity of the pulmonary disease may explain reduced culture conversion at this top quartile of rifampicin exposure.

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