Amelogenesis imperfecta caused by N-terminal enamelin point mutations in mice and men is driven by endoplasmic reticulum stress.

Hum Mol Genet · 2017 · PMC5411757 · PMID 28334996

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likely to be significantno p-value reported

However, the replacement of the relatively small polar amino acid serine with the larger non-polar hydrophobic amino acid isoleucine is likely to be significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.