The translationally relevant mouse model of the 15q13.3 microdeletion syndrome reveals deficits in neuronal spike firing matching clinical neurophysiological biomarkers seen in schizophrenia.

However, while PCs in Df(h15q13)/+ mice displayed a clear reduction in mean firing rate during the steady‐state phase for the frequency interval tested (20–80 Hz), interneurones only showed a tendency towards reduced mean firing which did not quite reach significance (mean firing rate for PCs and FSIs in mutants was on average: 45.5% and 94.5% of those in wt mice; anova main effect of genotype, P < 0.001, F = 20.13 and P = 0.0586, F = 3.59 respectively; post hoc test showed a significant genotype difference for PCs for all frequencies except 20 Hz; Fig. 3 a–d).

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