The Epstein-Barr virus miR-BHRF1-1 targets RNF4 during productive infection to promote the accumulation of SUMO conjugates and the release of infectious virus.

PLoS Pathog · 2017 · PMC5413087 · PMID 28414785

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highly significantno p-value reported

A highly significant reduction of the inhibitory effect of miR-BHRF1-1 was observed when the RNF4-3’UTR seed sequence TCAGGTT was mutated to T ACA GTT whereas a weaker but still significant reduction was observed with the TCA ATC T mutant ( Fig 5B ), which may be due to different effects of the mutations on the affinity of binding to the RNF4 mRNA.

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