Toward a Rapid Production of Multivirus-Specific T Cells Targeting BKV, Adenovirus, CMV, and EBV from Umbilical Cord Blood.

Although the strategy to develop a single culture of multi-VSTs is not novel per se, the clinical need for rapid manufacture of CB-derived multi-VSTs is highly significant and well established. 25 The ability to rapidly expand polyclonal CD4 + and CD8 + T cells from the 20% fraction in numbers feasible for multiple doses makes it an attractive option for both adult and larger pediatric recipients of CBT, where the number of nucleated cells is a limiting factor.

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