Inhibition of Mef2a Enhances Neovascularization via Post-transcriptional Regulation of 14q32 MicroRNAs miR-329 and miR-494.

Although inhibition of Mef2a was less strong than in vitro cell cultures, inhibition was highly significant (72% expression of control, p = 0.00052 in the adductor, and 78% expression of control, p < 0.0001 in the gastrocnemius muscle).

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Inhibition of Mef2a led to significant downregulation of 14q32 microRNA miR-329 ( Figure 6 A; p = 0.0026) and a borderline significant downregulation of miR-494 ( Figure 6 B; p = 0.06).

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