Sustained Inhibition of HBV Replication In Vivo after Systemic Injection of AAVs Encoding Artificial Antiviral Primary MicroRNAs.

Mol Ther Nucleic Acids · 2017 · PMC5415967 · PMID 28624194

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may be significantno p-value reported

Assessment of Toxic and Immunostimulatory Effects following Administration of scAAV8 miR-31/5,8,9 and scAAV8 miR-31/5 to HBV Transgenic Mice Toxicity caused by overexpression of RNAi activators may be significant and is potentially lethal. 12 , 18 Several analyses were therefore carried out to exclude toxicity of scAAV8 miR-31/5,8,9 and scAAV8 miR-31/5.

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