Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes.

Although there was marked variation in average X expression between individual replicates at this age, there was a highly significant upregulation of the X chromosome in X E O, Sry males relative to wild type XY males, and this was largely corrected in X E,Z2 O, Sry .

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Consistent with the gene expression data, there was a borderline significant increase in the number of tubules containing apoptotic cells in X E O, Sry , together with a highly significant increase in the number of apoptotic cells per tubule.

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