Low-Dose Dose-Response for In Vitro Nrf2-ARE Activation in Human HepG2 Cells.

Dose Response · 2017 · PMC5418914 · PMID 28515676

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closest p · 0.0× alpha

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highly significantP = 4 × 10 −5actually significant

Three-parameter linear/ k th-power regression fits obtained to each combined set of ARE- bla - or ARE- luc -assay response data provided good fits ( R 2 = .99 or .91, respectively, P fit > .99) that each incorporate a highly significant negative initial linear slope ( P = 4 × 10 −5 or .00025) and an overall J-shaped DR pattern.

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