In the case of stroke, it is conceivable from the model that the weaker pathophysiological relation- ship between LDL cholesterol and atherosclerotic stroke might fail to be exposed altogether in non- interventional observational studies, giving the impres- sion that LDL cholesterol is not a risk factor for athero- sclerotic stroke", yet drug-induced reductions of LDL cholesterol might indicate a highly significant relationship between the two.
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