Low LDL cholesterol, <i>PCSK9</i> and <i>HMGCR</i> genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study.

Observationally, there was a statistically significant trend for a higher risk of Parkinson’s disease across categories of lower LDL cholesterol levels (P=0.009 for categories and P=0.001 for fifths), but at most a borderline significant association between continuous LDL cholesterol levels and Parkinson’s disease (hazard ratio for a 1 mmol/L lower LDL cholesterol level was 1.10 (95% confidence interval 1.00 to 1.21); P=0.05).

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