TRPV2 knockout mice demonstrate an improved cardiac performance following myocardial infarction due to attenuated activity of peri-infarct macrophages.

The animals injected with KO macrophages presented an intermediate initial EF of 38.8 ± 3.1% which is higher than the baseline EF of the non-surviving WT-injected mice, with a trend towards significance (p = 0.06) and somewhat lower than the baseline EF of the animals which have survived the inoculation of the WT macrophages (p = 0.2) ( Fig 5B ).

also in 2,760 other papers