Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors.

Oncotarget · 2017 · PMC5421858 · PMID 28107190

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highly significantno p-value reported

Images acquired 30 min after [ 18 F]-FLac delivery revealed that MCT1 inhibition by AR-C155858 induced a highly significant decrease in tracer uptake in the tumors, liver and gut (Figure 4C & 4D and Supplementary Video 1 ).

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