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A decade of adverse drug events in Portuguese hospitals: space-time clustering and spatial variation in temporal trends.

BMC Pharmacol Toxicol · 2017 · PMC5424420 · PMID 28486949

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an increasing trendno p-value reported
A large number of studies points towards an increasing trend of ADR over time [ 38 – 40 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.