Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing.

Notably, KD of these genes showed increased amounts of aSMA immunopositivity, which was highly significant for Has2 KD, suggesting increased numbers of myofibroblasts.

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The KD of the transcription factor (TF) Egr2 had the broadest effect by reducing the levels of Col1a1 and Col3a1 mRNA as well as the percent area immunopositive for aSMA, IBA-1, and collagen proteins, although the reduction in collagen by half did not achieve significance ( Figure 2 ; Table 1 ).

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