Time-Resolved Transcriptomics and Constraint-Based Modeling Identify System-Level Metabolic Features and Overexpression Targets to Increase Spiramycin Production in <i>Streptomyces ambofaciens</i>.

Front Microbiol · 2017 · PMC5427115 · PMID 28553270

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a decreasing trendno p-value reported

ambofaciens experiences a decreasing trend in the number of flux-carrying reactions ( Figure 4 ) reflecting with both the reduced growth rate and lower spiramycin productivity observed in vivo in last phases of the growth.

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