Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence.

Sci Rep · 2017 · PMC5428349 · PMID 28232735

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highly significantno p-value reported

However, the highly significant defect in the Toll-like receptor (TLR)-induced cytokine production in monocytes and plasmacytoid dendritic cells (pDC) and in the pDC-induced functional activity of CD8 + T cells observed in the elderly may result from decreased TLR surface expression and dysfunctional IFN regulatory factor 7 (IRF7) 49 – 51 .

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