Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response.

23 However, the authors also observed a nonsignificant trend for patients with low TPMT activity to have higher incidence and shorter onset of secondary acute myeloid leukemia as well as higher cumulative incidence of brain tumors when compared with patients with wild-type. 52 , 53 In their later trial, Total Therapy Study XIIIB, which included 247 patients

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