Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia.

In the last two blocks Gria1 −/− mice showed a slightly higher level of discrimination than WT mice, however the genotype by block interaction failed to reach significance (F(7,329) = 2.31, p = 0.054), Both genotypes, however, showed an increase in performance over blocks (WT, F(7,168) = 5.80, p < 0.001; Gria1 −/− , F(7,161) = 12.29, p < 0.001).

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