MicroRNA regulation of progesterone receptor in breast cancer.

Interestingly, we found opposite trends in these two breast tumor subgroups: while PR up-regulated tumors displayed a significant negative correlation between miR-26b and PR mRNA expression fold changes (Figure 5C ), a marginally significant negative correlation between miR-23a and PR mRNA expression fold changes (Figure 5B ), and weak and insignificant negative correlation between miR-181a and PR mRNA expression fold changes (Figure 5A ), PR expression fold changes correlated negatively only with miR-181a expression fold changes (marginally significant) in PR down-regulated tumors (Figure 5A ).

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Moreover, the strong and significant positive correlation between the relative expressions of miR-181a and miR-23a or miR-26b in the normal surrounding tissues, and the fact that the relative expressions’ correlation between all the three miRNAs is stronger and highly significant when comparing the tumor samples, suggest that they are jointly regulated in normal breast tissues, and to an even higher extent in malignant breast tissue.

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