Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer <i>in vitro</i> and <i>in vivo</i>.

Chem Sci · 2017 · PMC5433508 · PMID 28553505

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an increasing trendno p-value reported

To confirm the mechanisms for the therapeutic efficacy of LYN-1604 in vivo , we examined the immunoreactivity of ULK1 and p-ULK1 in tumor tissues, and found both of them showed an increasing trend in LYN-1604-treated tumor tissues ( Fig. 10E and F ).

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