Age, gender, neck circumference, and Epworth sleepiness scale do not predict obstructive sleep apnea (OSA) in moderate to severe chronic obstructive pulmonary disease (COPD): The challenge to predict OSA in advanced COPD.

hospitalizations, and has become the 3 rd leading cause of death in the U.S.[ 1 – 6 ] Obstructive sleep apnea (OSA) is characterized by periods of partial or total intermittent collapse of the upper airway, resulting in nocturnal hypoxemia and arousals from sleep.[ 7 – 9 ]US data (2007–10) indicate an increasing trend with 26% of adults estimated to have mild to severe OSA, and even higher rates have been reported in some European Countries.[ 10 , 11 ] Flenley coined the term “overlap syndrome” when COPD and OSA coexist.[ 9 ] The prevalence of OSA among COPD subjects has been reported in different studies to ran

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