An integrative analysis of tissue-specific transcriptomic and metabolomic responses to short-term dietary methionine restriction in mice.

The expression profile of NFE2L2 target genes ( Fig 4A ) demonstrates a majority of such genes to have highly significant differences in mean expression between MR and Control samples (adjusted p ≤ 0.05 for 18/21 genes) with moderate to large effect sizes (absolute fold-changes 2-fold or higher).

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