close to significanceP-value = 0.0651
By χ 2 tests 30 over the 2 × 2 mutation count table regarding three types of non-synonymous sites (See Materials and Methods), we identified the signature of AS which showed statistical significance in DNS variants (P-value = 0.0114), close to significance in INS variants (P-value = 0.0651), and no significance in NNS variants (P-value = 0.2735) (Table 1 ).