External validation of SAPS 3 and MPM<sub>0</sub>-III scores in 48,816 patients from 72 Brazilian ICUs.

At the other extreme, one must be cautious in the interpretation of calibration results with small cohorts, because, even when the calibration curve, the calibration intercept and slope points to a miscalibration, the p values of traditional calibration statistics may not be significant, raising concern about the study low power [ 25 ].

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There is a known phenomenon with traditional calibration statistics (such as Hosmer–Lemeshow goodness of fit) in prediction models validation/calibration studies with many thousands included subjects, in which often p values are highly significant despite visually good calibration curves, very small absolute errors, and acceptable calibration slope and intercept.

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